The engineered E2 element of the GTU® vector allows for more persistent expression of genes in both non-dividing and dividing cells. It is non-viral, which means that there is neither risk of vector replication nor integration of unwanted DNA into the patient's genome. GTU has been tested in 10 clinical trials to date. It has been found is safe and well tolerated according to several national regulatory authorities.
Thanks to our engineered E2 element we can overcome the inherent weakness of tissue-specific promoters, enabling better expression of genes where needed. We have vectors available for a range of tissues.
Our new gtGTU(R) technology enables the expression of several new types of strong and persistent genes. Expression of, for instance a therapeutic antibody, can be sustained for up to months, challenging current therapeutic modalities.
We are concerned with the growing global problem of antibiotic resistance, and have developed a proprietary technology that allows completely antibiotic-free production of therapeutics.
Todorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C.
Sci Rep. 2017 Jun 23;7(1):4122
Read moreTodorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C.
Sci Rep. 2017 Jun 23;7(1):4122
Read moreTodorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C.
Sci Rep. 2017 Jun 23;7(1):4122
Read moreTodorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C.
Sci Rep. 2017 Jun 23;7(1):4122
Read more
