Our technology

Research papers

  • Combined skin and muscle vaccination differentially impact the quality of effector T cell functions: the CUTHIVAC-001 randomized trial. Haidari G, Cope A, Miller A, Venables S, Yan C, Ridgers H, Reijonen K, Hannaman D, Spentzou A, Hayes P, Bouliotis G, Vogt A, Joseph S, Combadiere B7, McCormack S, Shattock RJ. Sci Rep. 2017 Oct 12;7(1):13011 .
    Read more here.
  • Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques. Todorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C. Sci Rep. 2017 Jun 23;7(1):4122
    Read more here.
  • Therapeutic immunisation plus cytokine and hormone therapy improves CD4 T-cell counts, restores anti-HIV-1 responses and reduces immune activation in treated chronic HIV-1 infection. Herasimtschuk A, Downey J, Nelson M, Moyle G, Mandalia S, Sikut R, Adojaan M, Stanescu I, Gotch F, Imami N. Vaccine. 2014 Dec 5;32(51):7005-7013
    Read more here.
  • Enhanced immunogenicity of an HIV-1 DNA vaccine delivered with electroporation via combined intramuscular and intradermal routes. Mann JF, McKay PF, Fiserova A, Klein K, Cope A, Rogers P, Swales J, Seaman MS, Combadiere B, Shattock RJ. J Virol. 2014 Jun;88(12):6959-69
    Read more here.
  • Indicators of therapeutic effect in FIT-06, a Phase II trial of a DNA vaccine, GTU®-Multi-HIVB, in untreated HIV-1 infected subjects. Vardas E, Stanescu I, Leinonen M, Ellefsen K, Pantaleo G, Valtavaara M, Ustav M, Reijonen K. Vaccine. 2012 Jun 8;30(27):4046-54
    Read more here.
  • Immunization with dendritic cells transfected in vivo with HIV-1 plasmid DNA induces HIV-1-specific immune responses.  Malm M, Krohn K, Blazevic V. Arch Virol. 2011 Sep;156(9):1607-10
    Read more here.
  • Effective Formation of the Segregation-Competent Complex Determines Successful Partitioning of the Bovine Papillomavirus Genome during Cell Division. Silla T, Männik A, Ustav M.J Virol. 2010 Nov; 84(21): 11175–11188
    Read more here.
  • Elicitation of broad CTL response against HIV-1 by the DNA vaccine encoding artificial multi-component fusion protein MultiHIV-study in domestic pigs. Mölder T, Adojaan M, Kaldma K, Ustav M, Sikut R. Vaccine. 2009 Dec 11;28(2):293-8
    Read more here.
  • Persistent immune responses induced by a human immunodeficiency virus DNA vaccine delivered in association with electroporation in the skin of nonhuman primates. Martinon F, Kaldma K, Sikut R, Culina S, Romain G, Tuomela M, Adojaan M, Männik A, Toots U, Kivisild T, Morin J, Brochard P, Delache B, Tripiciano A, Ensoli F, Stanescu I, Le Grand R, Ustav M. Hum Gene Ther. 2009 Nov;20(11):1291-307
    Read more here.
  • Combining DNA technologies and different modes of immunization for induction of humoral and cellular anti-HIV-1 immune responses.  Bråve A, Hallengärd D, Malm M, Blazevic V, Rollman E, Stanescu I, Krohn K. Vaccine. 2009 Jan 7;27(2):184-6. doi: 10.1016/j.vaccine.2008.10.041
    Read more here.
  • GTU-MultiHIV DNA vaccine results in protection in a novel P815 tumor challenge model.  Malm M, Sikut R, Krohn K, Blazevic V. Vaccine. 2007 Apr 30;25(17):3293-301
    Red more here.
  • Induction of human immunodeficiency virus type-1-specific immunity with a novel gene transport unit (GTU)-MultiHIV DNA vaccine.  Blazevic V, Männik A, Malm M, Sikut R, Valtavaara M, Toots U, Ustav M, Krohn K. AIDS Res Hum Retroviruses. 2006 Jul;22(7):667-77
    Read more here.
  • Cross-clade protection induced by human immunodeficiency virus-1 DNA immunogens expressing consensus sequences of multiple genes and epitopes from subtypes A, B, C, and FGH.  Malm M, Rollman E, Ustav M, Hinkula J, Krohn K, Wahren B, Blazevic V. Viral Immunol. 2005;18(4):678-88
    Read more here.
  • A DNA HIV-1 vaccine based on a fusion gene expressing non-structural and structural genes of consensus sequence of the A-C subtypes and the ancestor sequence of the F-H subtypes. Preclinical and clinical studies.  Krohn K, Stanescu I, Blazevic V, Vesikari T, Ranki A, Ustav M. Microbes Infect. 2005 Nov;7(14):1405-13
    Read more here.
  • Biodistribution and general safety of a naked DNA plasmid, GTU-MultiHIV, in a rat, using a quantitative PCR method. Tuomela M, Malm M, Wallen M, Stanescu I, Krohn K, Peterson P. Vaccine. 2005 Jan 4;23(7):890-6
    Read more here.
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Antibiotic-free

We are concerned with the growing global problem of antibiotic resistance, and have developed a proprietary technology that allows completely antibiotic-free production of therapeutics.

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List of publications

Electroporation as a vaccine delivery system and a natural adjuvant to intradermal
administration of plasmid DNA in macaques.

Todorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C.

Sci Rep. 2017 Jun 23;7(1):4122

Read more

Electroporation as a vaccine delivery system and a natural adjuvant to intradermal
administration of plasmid DNA in macaques.

Todorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C.

Sci Rep. 2017 Jun 23;7(1):4122

Read more

Electroporation as a vaccine delivery system and a natural adjuvant to intradermal
administration of plasmid DNA in macaques.

Todorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C.

Sci Rep. 2017 Jun 23;7(1):4122

Read more

Electroporation as a vaccine delivery system and a natural adjuvant to intradermal
administration of plasmid DNA in macaques.

Todorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C.

Sci Rep. 2017 Jun 23;7(1):4122

Read more

List of publications:

  • Combined skin and muscle vaccination differentially impact the quality of effector T cell functions: the CUTHIVAC-001 randomized trial. Haidari G, Cope A, Miller A, Venables S, Yan C, Ridgers H, Reijonen K, Hannaman D, Spentzou A, Hayes P, Bouliotis G, Vogt A, Joseph S, Combadiere B7, McCormack S, Shattock RJ. Sci Rep. 2017 Oct 12;7(1):13011 .
    Read more here.
  • Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques. Todorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C. Sci Rep. 2017 Jun 23;7(1):4122
    Read more here.
  • Therapeutic immunisation plus cytokine and hormone therapy improves CD4 T-cell counts, restores anti-HIV-1 responses and reduces immune activation in treated chronic HIV-1 infection. Herasimtschuk A, Downey J, Nelson M, Moyle G, Mandalia S, Sikut R, Adojaan M, Stanescu I, Gotch F, Imami N. Vaccine. 2014 Dec 5;32(51):7005-7013
    Read more here.

List of publications:

  • Combined skin and muscle vaccination differentially impact the quality of effector T cell functions: the CUTHIVAC-001 randomized trial. Haidari G, Cope A, Miller A, Venables S, Yan C, Ridgers H, Reijonen K, Hannaman D, Spentzou A, Hayes P, Bouliotis G, Vogt A, Joseph S, Combadiere B7, McCormack S, Shattock RJ. Sci Rep. 2017 Oct 12;7(1):13011 .
    Read more here.
  • Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques. Todorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C. Sci Rep. 2017 Jun 23;7(1):4122
    Read more here.
  • Therapeutic immunisation plus cytokine and hormone therapy improves CD4 T-cell counts, restores anti-HIV-1 responses and reduces immune activation in treated chronic HIV-1 infection. Herasimtschuk A, Downey J, Nelson M, Moyle G, Mandalia S, Sikut R, Adojaan M, Stanescu I, Gotch F, Imami N. Vaccine. 2014 Dec 5;32(51):7005-7013
    Read more here.